Abstract:

AIM: To evaluate the efficacy and safety of vancomycin calcium sulfate combined with ultrashort wave in the treatment of traumatic osteomyelitis. METHODS: Severty-four cases of traumatic osteomyelitis were randomly divided into control group and treatment group (37 cases each).The control group was given hydrochloric acid (0.8 g/d) for 3 days (2 times a day) before surgery.Selection of calcium sulfate bone graft substitute (5-10 g) and hydrochloric acid (1 g) were added to make paste. Hydrochloric acid (0.8 g/d) was given after the operation.The treatment group received ultra-short wave therapy after operation and all patients were treated for 28 days.The clinical effects, hemorheology index,the serum C- reactive protein (CRP), serum tumor necrosis factor (TNF-α),nuclear factor kappa B (NF-κB),and adverse reactions were compared between the two groups. RESULTS: After treatment, the total effective rate in the control group was (78.38%),which was significantly lower than that in the experimental group (97.30%) (P<0.05). After treatment, the erythrocyte aggregation index of the experimental group was higher than that of the control group (P<0.05).Plasma viscosity, whole blood viscosity and ESR level were lower than the control group(P<0.05).Levels of serum CRP,TNF-α and NF-κB in the experimental group were significantly lower than those in the control group (P<0.05).Levels of serum CRP,TNF-α and NF-κB were significantly lower than control group (P<0.05).The adverse reaction rate of control group was 13.51%,the treatment group was 8.11%,and the difference was not statistically significant (P> 0.05). CONCLUSION: Vancomycin calcium sulfate combined with ultrashort wave in the treatment of traumatic osteomyelitis is effective and safe.

Key words: vancomycin, calcium sulfate, ultrashort wave, traumatic osteomyelitis, clinical efficacy, safety