Effect of Xuesaitong soft capsule on acute lacunar cerebral infarction combined with cerebral microbleeds

Abstract

Abstract:

AIM: To evaluate the clinical efficacy of Xuesaitong soft capsule in the treatment of acute lacunar cerebral infarction combined with cerebral microbleeds and its influence on S100B and soluble receptor for advanced glycation end products (sRAGE) in serum. METHODS: Eighty-six patients with acute lacunar cerebral infarction and cerebral microbleeds were randomly divided into control group and treatment group, 43 cases in each group. Control group received basic treatment. Treatment group were treated with Xuesaitong soft capsule additionally for a course of 8 weeks. Clinical efficacy, scores of CSS, NIHSS and MRS, levels of S100B and sRAGE in serum and adverse reactions were compared between the two groups. RESULTS:The effective rate in treatment group was 90.70%, significantly higher than 74.42% in control group (P<0.05). After treatment, scores of CSS and NIHSS in treatment group were significantly lower than those in control group (P<0.01). The level of S100B in serum in treatment group was significantly lower than that in control group (P<0.05), and the level of sRAGE in serum in treatment group was significantly higher than that in control group (P<0.05). During treatment, no significant adverse reactions were exhibited. CONCLUSION: Xuesaitong soft capsule has obvious curative effect on acute lacunar cerebral infarction combined with cerebral microbleeds, which is referential for clinical application.

Key words: cerebral microbleeds, xuesaitong soft capsule, acute lacunar cerebral infarction, S100B, soluble receptor for advanced glycation end products

CLC Number:

R743

WANG Meihua, WENG Qiuyan, ZHA Qin, NIU Yanfang. Effect of Xuesaitong soft capsule on acute lacunar cerebral infarction combined with cerebral microbleeds[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(5): 574-579.

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