Comparison of pharmacodynamics of Fufang lujiao rutongning capsule and its original formula

Abstract

Abstract:

AIM: To compare the therapeutic and analgesic effect of improved Fufang lujiao rutongning capsule and its original formula on hyperplasia of mammary glands in rats. METHODS: The model of mammary glands hyperplasia was induced by intramuscular injection of estradiol and progesterone so as to evaluate the action receptors in breast issues and the serum levels of hormone and to compare the therapeutic effect of both formulas. In the analgesic experiment, glacial acetic acid was used to induce writhing to compare the time of latency, number of writhing and of analgesic rate of the two formulas. RESULTS: Both formulas of Rutongning capsule could alleviate the breast hyperplasia, while the improved formula presented better therapeutic and analgesic effect. CONCLUSION: Fufang lujiao rutongning capsule is better than Rutongning capsule for controlling hyperplasia pain.

Key words: Fufang lujiao rutongning capsule, Rutongning capsule, hyperplasia of mammary glands, analgesia

CLC Number:

R965.2

LENG Xiaowei, Rita, LI Min, ZHANG Tong, REN Liqun, FAN Zhimin. Comparison of pharmacodynamics of Fufang lujiao rutongning capsule and its original formula[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2017, 22(8): 852-858.

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