| ［1］Werner J, Combs SE, Springfeld C, et al. Advanced-stage pancreatic cancer: therapy options［J］. Nat Rev Clin Oncol, 2013, 10(6):323-333.
［2］Zhang Z, Liu S, Xiong H, et al. Electrospun Pla /Mwcnts composite nanofibers for combined chemo- and photothermal therapy ［J］. Acta Biomater, 2015, 26: 115-123．
［3］Vaupel P,Kelleher DK,Hockel M.Oxygen status of malignanttumors: pathogenesis of hypoxia and significance fortumor therapy［J］.Semin Oncol,2001,28(2 Suppl 8):29-35．
［4］Iwatsuki M,Mimori K,Yokobori T,et al.Epithelial-mesenchymal transition in cancer development and its clinical significance［J］.Cancer Sci,2010,101(2):293-299.
［5］Zhang Y, Li M, Yao Q, et al. Recent advances in tumor hypoxia:tumor progression, molecular mechanisms, and therapeutic implications［J］. Med Sci Monit, 2007, 13(10): RA175-180.
［6］Sun LL, Song Z, Li WZ, et al. Hypoxia facilitates epithelial-mesenchymal transition-mediated rectal cancer progress ［J］. Genet Mol Res, 2016, 15(4). DOI: 10.4238/gmr15048936.
［7］Chen S, Chen JZ, Zhang JQ, et al. Hypoxia induces TWIST-activated epithelial-mesenchymal transition and proliferation of pancreatic cancer cells in vitro and in nude mice［J］.Cancer Lett, 2016, 383(1):73-84.
［8］Huang CH, Yang WH, Chang SY, et al. Regulation of membrane-type 4 matrix metalloproteinase by slug contributes to hypoxia-mediated metastasis［J］. Neoplasia，2009, 11(12):1371-1382.
［9］Zhou BP, Deng J, Xia W, et al. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition［J］. Nat Cell Biol, 2004, 6(10) : 931-940．
［10］苏兆亮，刘嫣方，宋濂，等.低氧诱导高迁移率组蛋白B1对人胰腺癌细胞凋亡抵抗和迁移的作用研究［J］. 海军医学杂志,2016,37(5):404-407.
［11］Goard CA, Schimmer AD. An evidence-based review of obatoclax mesylate in the treatment of hematological malignancies［J］. Core Evid，2013, 8:15-26.
［12］Konopleva M, Watt J, Contractor R, et al. Mechanisms of antileukemic activity of the novel BCL-2 homology domain-3 mimetic GX15-070 (obatoclax) ［J］. Cancer Res, 2008, 68(9):3413-3420. |
