Influence of genetic variation of TNFAIP3 on prognosis among esophageal squamous cell carcinoma patients

doi:10.12092/j.issn.1009-2501.2018.07.016

Abstract

Abstract:

AIM: To investigate the influence of genetic variation of tumor necrosis factor alpha induced protein 3 (TNFAIP3) on prognosis among esophageal squamous cell carcinoma patients. METHODS: A total of 175 patients underwent complete surgical resection of esophageal squamous cell carcinoma were included in this study. 5 mL peripheral blood specimen of the patient was collected. Genomic DNA were extracted and genotype of rs583522 were analyzed. The association between genotype and baseline clinical characteristics and prognosis were analyzed. RESULTS: Wild type AA genotypes showed advanced tumor stages compared with those of homozygous G-allele carriers (P<0.001). Patients with an AA genotype were significantly more likely to experience relapse (P=0.022). Survival analysis revealed a significant difference in overall survival between different genotype groups (P=0.017). CONCLUSION: rs583522 genotypes can be used as biomarkers to evaluate the prognosis of patients with esophageal squamous carcinoma.

Key words: esophageal squamous carcinoma, TNFAIP3, polymorphism, prognosis

CLC Number:

R968

SHAN Yan, LI Zhigang. Influence of genetic variation of TNFAIP3 on prognosis among esophageal squamous cell carcinoma patients[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(7): 820-824.

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