Experimental study on the effect of total flavonoids of Pueraria lobata on inflammatory cytokines in rats with inner ear injury induced by isoproterenol

doi:10.12092/j.issn.1009-2501.2018.09.006

Abstract

Abstract:

AIM: To investigate the effect of total flavonoids of Pueraria lobata on inflammatory factors after isoprenaline induced inner ear injury in rats. METHODS: The rats were divided into four groups: the high and low dose group of total flavonoids of Pueraria lobata, the model group and the negative group. The changes of TNF-α, IL-4, ACTH and Bax protein in rats with inner ear injury induced by isoproterenol were observed and compared.RESULTS:Compared with the negative group, the serum TNF-α, IL-4, ACTHX, Bax content in the administration group and the model group was significantly higher than that in the model group (P＜0.05), and was significantly higher than those in the model group (P<0.05). The content of TNF- α, IL-4, Bax in serum decreased (P<0.05) and the content of ACTH increased in the treatment group (P<0.05), especially in the high-dose group compared with the low-dose group (P<0.01). CONCLUSION: Total flavonoids of Pueraria lobata can effectively inhibit the release of TNF-α, IL-4 inflammatory factor and regulate the expression of ACTH, Bax protein in rat inner ear injury induced by isoprenaline.

Key words: total flavonoids of Pueraria lobata, inner ear injury, TNF-α, IL-4, ACTHX, Bax

CLC Number:

R965.2

ZHAO Jiangtao, LIANG Yange. Experimental study on the effect of total flavonoids of Pueraria lobata on inflammatory cytokines in rats with inner ear injury induced by isoproterenol[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(9): 1003-1007.

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