Effects of medicated bath hydrotherapy combined with Yinzhihuang oral liquid on neonatal jaundice

doi:10.12092/j.issn.1009-2501.2018.09.013

Abstract

Abstract:

AIM: To observe the therapeutic effect of medicated bath hydrotherapy combined with Yinzhihuang oral liquid on neonatal jaundice. METHODS: A total of 392 neonates with jaundice were selected from March 2016 to January 2018 in our hospital, which were randomly divided into hydrotherapy group and shower group, each with 196 cases. Both groups took Yinzhihuang oral liquid. The hydrotherapy group was supplemented with medicated bath hydrotherapy, and the shower group was given routine shower. The following indexes, including jaundice index, jaundice regression time, weight change, TBIL, ALT, TBA, CRP, IL-6, IL-8, IgA, IgG and IgM levels, and changes in red cell immune function were compared between these two groups. RESULTS:After treatment, the jaundice index of the medicated bath hydrotherapy group was lower than that of the shower group, and the regression time of the jaundice was significantly shorter, while the weight of the children after treatment was higher than that of the shower group with significant differences (P<0.05). After treatment, serum levels of TBIL, ALT, and TBA in the medicated bath hydrotherapy group were lower than those in the shower group, and the difference was statistically significant (P<0.05). The levels of serum CRP, IL-6, and IL-8 in the Chinese medicine hydrotherapy group were lower than those in the shower group, and the difference was significant (P<0.05). The plasma levels of IgA, IgG, IgM, and RBC-C3bR in the medicated bath hydrotherapy group were significantly higher than those in the shower group. The difference was statistically significant (P<0.05). CONCLUSION: The treatment of Yinzhihuang oral liquid supplemented with medicated bath hydrotherapy can effectively improve the neonatal jaundice and contribute to the improvement of children's immunity.

Key words: neonatal jaundice, Yinzhihuang oral liquid, medicated bath hydrotherapy, shower

CLC Number:

R722.17

LI Yongpei, ZHU Yunxia, HUANG Ting. Effects of medicated bath hydrotherapy combined with Yinzhihuang oral liquid on neonatal jaundice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2018, 23(9): 1047-1051.

References

［1］Cortey A, Renesme L, Raignoux J ,et al. Management of jaundice in the newborn ≥ 35 GW: From screening to follow-up after discharge. Guidelines for clinical practice［J］. Arch Pediatr, 2017, 24(2):192-203.
［2］Bhutani VK. Editorial: building evidence to manage newborn jaundice worldwide［J］. Indian J Pediatr, 2012, 79(2):253-255.
［3］Wan A, Mat DS, Teh SH,et al. Management of neonatal jaundice in primary care［J］. Malays Fam Physician, 2016, 11(2-3):16-19.
［4］Mitra S, Rennie J. Neonatal jaundice: aetiology, diagnosis and treatment［J］. Br J Hosp Med (Lond), 2017, 78(12):699-704.
［5］Basiri-Moghadam M, Basiri-Moghadam K, Kianmehr M ,et al. The effect of massage on neonatal jaundice in stable preterm newborn infants: a randomized controlled trial［J］. J Pak Med Assoc, 2015, 65(6):602-606.
［6］Madan A. Phototherapy: old questions, new answers［J］. Acta Paediatr, 2005, 94(10):1360-1362.
［7］王国杰,李然,康永明. 茵栀黄颗粒治疗新生儿病理性黄疸的临床观察［J］. 中医药信息,2011,28(4):121-122.
［8］赵丹丹,李敏,高翔羽,等. 茵栀黄口服液治疗新生儿高胆红素血症临床观察［J］. 中华针灸电子杂志,2017,6(2):84-88.
［9］陈丽娟. 中药水疗早期干预新生儿黄疸的效果及护理［J］. 中国现代药物应用,2018,12(8):208-209.
［10］中华医学会儿科学分会新生儿学组. 新生儿高胆红素血症诊断和治疗专家共识［J］. 中华儿科杂志, 2014, 52(10):745-748.
［11］Ahlfors CE, Parker AE. Unbound bilirubin concentration is associated with abnormal automated auditory brainstem response for jaundiced newborns［J］. Pediatrics, 2008, 121(5):976-978.
［12］周良燕,王静,黄丹. 茵栀黄口服液在治疗新生儿高胆红素血症中的应用价值［J］. 当代医药论丛,2018,16(3):6-7.
［13］陈利玲. 茵栀黄口服液治疗新生儿黄疸的临床疗效分析［J］. 内蒙古中医药,2016,35(1):13-14.
［14］曾小华, 朱湘陵, 冯兰青, 等. 药浴水疗对早产儿及低体重儿胆红素及血糖的影响［J］. 广东医学, 2012,33(12):1817-1819.
［15］伏裕,张晓. 早期抚触水疗护理在新生儿生理性黄疸防治中的作用分析［J］. 中外女性健康研究,2017(4):74-76.
［16］林玉波, 王永红, 蔡紫薇, 等. 游泳对新生儿黄疸的作用及相关机制研究［J］. 中国医药导报, 2013,10(29):18-20.
［17］曾红如, 陈丽茹, 李梅桂, 等. 药浴水疗对新生儿黄疸指数及生长发育的影响研究［J］. 海南医学院学报, 2012, 18(9):1315-1317.
［18］王利民, 武秀娟, 吴怀楚, 等. 药浴早期干预新生儿黄疸的临床效果研究［J］. 中国妇幼保健, 2010, 25(8):1058-1059.
［19］Webster GF, Webster TG, Grimes LR. Laboratory tests in patients treated with isotretinoin: occurrence of liver and muscle abnormalities and failure of AST and ALT to predict liver abnormality［J］. Dermatol Online J, 2017, 23(5). pii: 13030/qt7rv7j80p.
［20］Scuotto M, Persico M, Bucci M ,et al. Outstanding effects on antithrombin activity of modified TBA diastereomers containing an optically pure acyclic nucleotide analogue［J］. Org Biomol Chem, 2014, 12(28):5235-5242.
［21］刘艳薇, 董淑红, 魏锋, 等. 新生儿黄疸血清白细胞介素及红细胞免疫检测的临床价值［J］. 广东医学, 2017,38(20):3155-3157.
［22］顾岚, 宋国英, 张洁, 等. 新生儿黄疸红细胞免疫功能的变化［J］. 中外妇儿健康, 2011, 19(4):99-100.