Abstract:

AIM: To explore Sangbailishi decoction in the treatment of post infection cough (lung heat damp syndrome) and the effect on the level of substance P (SP) and calcitonin gene related peptide (CGRP) in induced sputum. METHODS: Sixty patients with post infection cough (lung heat damp syndrome) were divided into the treatment group and the control group. The control group received dextromethorphan chlorpheniramine pseudoephedrine. The treatment group was treated with Sangbailishi decoction. The time of cough remission and the frequency of coughing recurrence were recorded and compared between two groups. Cough symptom score was used to evaluate the change of patients' cough symptoms. The severity of coughing was assessed by visual imitative score (VAS). The symptoms of the patients were evaluated by the score of the syndrome. The levels of SP and CGRP were detected and compared betweeen the two groups before and after treatment. RESULTS:The total effective rate of the treatment group was higher than that of the control group (P<0.05). The time of cough remission and the number of coughing recurrences in the treatment group were lower than those in the control group (P<0.05). After treatment, The score of day cough score, night cough score, VAS score and syndrome effect score of the two groups were significantly reduced (P<0.05), and those of the treatment group were lower than those in the control group (P<0.05). After treatment, SP and CGRP were significantly decreased (P<0.05) and those of the treatment group were lower than those in the control group (P<0.05). CONCLUSION: Sangbailishi decoction is effective in the treatment of post infection coughing (lung heat damp syndrome), and can significantly reduce the level of SP and CGRP in induced sputum.

Key words: Sangbailishi decoction, coughing after infection, substance P, calcitonin gene related peptide