Abstract:

AIM: To investigate the effects of continuous intravenous microinfusion of hydrocortisone sodium succinate on hospitalization time, dynamic glycemic index and some vital signs in patients with severe septic shock. METHODS: A total of 142 cases of severe septic shock were selected in our hospital from January 2017 to February 2018 and were randomly divided into the study group and the control group, with 71 cases in each group. The study group was given hydrocortisone sodium succinate intravenous micro pump based on routine treatment, while control group received hydrocortisone sodium succinate intravenous drip treatment, the total hospitalization time, ICU hospitalization time and duration of shock, part of vital signs index, dynamic blood glucose index, blood lactate clearance etc. were observed and compared between two groups. RESULTS: After treatment, the total hospitalization time, ICU hospitalization time and duration of shock of the study group were less than those of the control group (P<0.05); and the heart rate (HR), mean arterial pressure (MAP), central venous pressure (CVP) and other indicators were significantly better than those of the control group (P<0.05). And the blood glucose fluctuation coefficient, maximum blood glucose fluctuations and high blood glucose level time window of the study group were significantly better than those of the control group; After treatment, blood lactate clearance rate of patients in the study group was significantly higher than that of the control group (P<0.05). CONCLUSION: Continuous intravenous microinfusion of hydrocortisone sodium succinate is effective in treating severe septic shock. Micropump can improve the metabolism level and blood glucose stability of patients, and it can be widely applied in clinic.

Key words: continuous, venous trace, pumping, severe sepsis, shock, effect, observation