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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2019, Vol. 24 ›› Issue (3): 318-326.doi: 10.12092/j.issn.1009-2501.2019.03.014

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Trimethylamine N-oxide and inflammatory disease

FANG Qing, OU-YANG Dongsheng   

  1. Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008,Hunan, China; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha 410078,Hunan, China; Hunan Key Laboratory for Bioanalysis of Complex Matrix Samples, Changsha 410000, Hunan, China
  • Received:2018-11-27 Revised:2018-12-21 Online:2019-03-26 Published:2019-04-01

Abstract:

High levels of intestinal flora metabolite Trimethylamine N-oxide can promote the development of inflammatory diseases. This reviews mainly discussed the relationship between the TMAO and inflammatory diseases, such as diabetes, atherosclerosis, heart failure and the potential molecular mechanisms of TMAO-induced inflammatory diseases.

Key words: gut microbiota, trimethylamine-N-oxide, inflammatory disease, probiotics

CLC Number: