Abstract:

AIM: To study the curative effect of Liangxuehuoxue Decoction combined with cupping therapy on plaque psoriasis.  METHODS:138 patients with plaque psoriasis from July 2015 to October 2017 in the Hangzhou Third People's Hospital were randomly divided into treatment group (69 cases) and control group (69 cases) by random number table method. Patients in the treatment group were treated with Liangxuehuoxue Decoction combined with cupping therapy, while patients in the control group were treated with Liangxuehuoxue Decoction only for 8 weeks and followed up for 6 months. The clinical efficacy, psoriatic lesion area and severity index (PASI score), skin CT changes, safety and recurrence of the two groups were observed. RESULTS:There were significant differences in clinical efficacy between the two groups (Z=-2.045，P=0.041). The effective rate of the treatment group was significantly higher than that of the control group (98.55% vs. 79.71%，χ2=12.641，P=0.000). After treatment 4 weeks, 6 weeks, 8 weeks, the traditional Chinese medical syndrome scores in the two groups of patients were significantly reduced, and the traditional Chinese medical symptom scores of the treatment group was significantly lower than that of the control group (P<0.05). After treatment, the PASI scores of the two groups were significantly reduced, and the PASI score of the treatment group was significantly lower than that of the control group (P<0.05). After treatment, the thickness of the spinous layer and the width of the nipple ring of the two groups were significantly reduced, and these two indicators in the treatment group were significantly lower than those in the control group (P<0.05). There were no obvious abnormalities in the three routine tests, coagulation function and biochemical examination before and after treatment. The recurrence rate of the treatment group was significantly lower than that of the control group (3.23% vs. 25.81%, χ2= 4.679, P=0.031). CONCLUSION:Liangxuehuoxue Decoction combined with cupping therapy can significantly improve the clinical efficacy and has high safety in the treatment of plaque psoriasis. Therefore, this treatment is worthy of clinical promotion.

Key words: plaque psoriasis, Liangxuehuoxue Decoction, cupping therapy, skin computed tomography