p73 gene and spermatogenesis and maturation

doi:10.12092/j.issn.1009-2501.2019.06.018

Abstract

Abstract:

p73 is a member of the p53 family. Its structure and function are very similar to p53. It has been well known in inhibiting the occurrence and development of tumors. Recent studies have found that p73 gene regulates spermatogenesis and maturation and affects male reproductive ability. Therefore, its unique role in male reproduction has attracted much attention. The p73 gene has two different functional subtypes (TAp73 and delta Np73), which not only affect the adhesion and migration between the germ cells and the Sertoli cells, but also affect the apoptosis of the sperm. In this paper, the structure of the p73 gene and its biological function in the maturation of germ cells will be briefly described in order to provide new ideas for the diagnosis and treatment of male reproductive system diseases.

Key words: p73 gene, male reproductive system, sperm apoptosis

CLC Number:

R699

WANG Tongsheng，WU Delin，LI Li, NA Sha. p73 gene and spermatogenesis and maturation[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2019, 24(6): 712-715.

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