Research progress in pharmacological effects and clinical applications of ebselen

doi:10.12092/j.issn.1009-2501.2020.02.018

Abstract

Abstract: Ebselen (EbSe) is a synthetic lipo-soluble selenium-containing organic small molecule compound with a wide range of physiological and pharmacological activities. EbSe is one of the most well-studied selenium-containing compounds. Early studies have shown that EbSe possess various bio-activities by eliminating intracellular oxygen free radicals and inhibiting lipid peroxidation. Recent studies have demonstrated that the multifarious biological activities of EbSe based on its selenium effect on the cysteine residues of substrates. Its potential clinical application range keeps expanding, which has a prospect application in the treatment of multiple system diseases in the human body. In addition, the latest study confirmed that EbSe has outstanding antibacterial activity against multidrug-resistant bacteria infections. Based on this, this article briefly reviews the research progress of pharmacological activities and related clinical applications of EbSe, providing some references for scientific research and clinical workers.

CLC Number:

R969
R961

ZHOU Jingxuan，WANG Peng，YUAN Chunling，WANG Jun，ZOU Lili. Research progress in pharmacological effects and clinical applications of ebselen[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(2): 233-240.

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