Anti-inflammatory and analgesic effects of total saponin of Dioscorea

doi:10.12092/j.issn.1009-2501.2020.03.003

Abstract

Abstract: AIM: To study the anti-inflammatory and analgesic effects of total saponin of Dioscorea(TSD). METHODS: The rat acute gouty arthritis (AGA) and the mice air-pouch inflammation models were induced by monosodium urate(MSU), the pain models were adopted including the hot-plate and acetic acid-induced writhing test in mice. Then the content of IL-1β, IL-18 and PGE2 levels were determined by ELISA. RESULTS:TSD significantly inhibited the MSU-induced ankle swelling and air pouch inflammation in mice(P<0.01 or P<0.05). Meanwhile, TSD markedly reduced the levels of IL-1β and IL-18 in synovial fluid exudates and IL-1β and PGE2 in air pouch exudates (P<0.01 or P<0.05).In addition, TSD remarkably suppressed acetic acid-induced writhing response and prolonged pain threshold in hot plate assay(P<0.01 or P<0.05).CONCLUSION: TSD has anti-inflammatory and analgesic effects, which are mainly relevant to the inhibition of the synthesis and release of inflammatory factors IL-1β, IL-18 and PGE2.

Key words: total saponin of Dioscorea, anti-inflammatory, analgesic

CLC Number:

R965.2

QI Qin, HE Xiang, WANG Gang, NA Sha, LV Lei, CHEN Guangliang. Anti-inflammatory and analgesic effects of total saponin of Dioscorea[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(3): 257-264.

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