Association between the polymorphism of PNPLA2 gene and the risk of ischemic stroke in type 2 diabetic patients in Chinese Han Population

doi:10.12092/j.issn.1009-2501.2020.06.009

Abstract

Abstract: AIM: To investigate the association between the polymorphism of the fatty triglyceride lipase gene (PNPLA2) rs1138693 (T>C) and the risk of ischemic stroke in type 2 diabetic patients in China. METHODS: A total of 368 Chinese patients with type 2 diabetes mellitus (T2DM) (139 T2DM ischemic stroke patients and 229 T2DM non-ischemic stroke patients were included as the control group) were included in this case-control study. PNPLA2 rs1138693 (T>C) was genotyped by real-time polymerase chain reaction (PCR) and statistically analyzed by SPSS 20.0. RESULTS: Significant differences were observed in age, sex, blood pressure and homocysteine levels between the control group and the ischemic stroke group (P<0.05). The CC genotype frequency and C allele frequency of PNPLA2 rs1138693 in the ischemic stroke group were significantly lower than those in the control group (genotype frequency: P=0.033; allele frequency: P=0.011). Logistic regression analysis revealed that allele C of PNPLA2 rs1138693 was a protective factor for progression to ischemic stroke in T2DM patients under the additive, dominant and recessive genetic models (P<0.05). CONCLUSION: The PNPLA2 gene rs1138693 is related to the susceptibility of Chinese T2DM patients to ischemic stroke, and the T2DM patients with allele C of rs1138693 are less likely to develop ischemic stroke.

Key words: ischemic stroke in type 2 diabetes mellitus, adipose triglyceride lipase gene, gene polymorphism

CLC Number:

R587.1

ZHAO Hailing, ZHANG Haojun, ZHAO Tingting, YAN Meihua, DONG Xi, MA Liang, LI Ping. Association between the polymorphism of PNPLA2 gene and the risk of ischemic stroke in type 2 diabetic patients in Chinese Han Population[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2020, 25(6): 664-669.

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