Advancement in research on precursor of brain derived neurotrophic factor

Abstract

Abstract: The neurotrophins are a family of growth factors belong to a class of secreted proteins, which participate in several physiological events of neural system. Recent studies indicate that pro-neurotrophins and their mature forms often have opposite function in biological effects,their receptors and the intracellular signaling pathways. The recent progress of precursor of brain derived neurotrophic factor(proBDNF), especially the distribution, biosynthesis, secretion, bioactivity of proBDNF and the relationship between proBDNF and neural system diseases are reviewed in this article.It is very important to study the function of proBDNF participated in the physiological and pathological conditions for drug researching and developing and for the treatment of nervous system diseases.

Key words: proBDNF, Distribution, Biosynthesis, Bioactivity

CLC Number:

BAI Xian-shu, LIAO Hong. Advancement in research on precursor of brain derived neurotrophic factor[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(6): 700-704.

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