Protective effects and the mechanisms of DEAAA on focal cerebral ischemia in rats

Abstract

Abstract: AIM: To study the protective effects of (E)-3-(4-(2-(dimethylamino) ethoxyl)-3-anisyl) acrylic acid(DEAAA) on focal cerebral ischemia of rats. METHODS: Middle cerebral artery occlusion(MCAO) model was used to evaluate the drug's effects. With Ozagrel as a positive control drug, after cerebral ischemia, the effect of different doses of DEAAA on the neurological behaviors, the cerebral water volumes, the cerebral infarction areas, the cerebral biochemistry and the pathologic change of brains were evaluated. RESULTS: DEAAA (30, 18 mg/kg) decreased the cerebral water volumes and the cerebral infarction areas(P<0.05, P<0.01), increased the levels of SOD and LDH, decreased the content of MDA in brain(P<0.05, P<0.01), improved neurological behaviors of the MCAO rats(P<0.05, P<0.01) and improved the pathologic change of brain after cerebral ischemia. CONCLUSION: DEAAA has the protective effects on cerebral ischemia in rats, the mechanisms of DEAAA involved in anti-oxidation, improving energy metabolism and increasing the ability of getting rid of free radicals.

Key words: Ozagrel, Focal cerebral ischemia, Protective effects, Anoxia

CLC Number:

R965.2

JI Rui, CHEN Li, WU Yu-lin. Protective effects and the mechanisms of DEAAA on focal cerebral ischemia in rats[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2010, 15(5): 502-506.

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