Abstract: AIM: To study the analgesic effect of lappaconitine in patients after cholecystecystectomy. METHODS: Fifty-six patients aging 20-65 were randomly divided into two groups (28 patients per group). Lappaconitine group received lappaconitine 40 mg and Fentanyl group fentanyl 0.4 mg. RESULTS: Compared with Lappaconitine group, the pain scaling of patients who received lappaconitine were similar to fentanyl (P>0.05),but there were significant differences on the side-effects such as itch of skin, nausea and vomiting between two groups (P＜0.01). CONCLUSION: Compared with Lappaconitine group, the pain feel ofthe patients who received fentanyl were equal, but the side effects such as itch of skin, nausea and vomiting in Lappaconitine group were less.

Key words: Lappaconitine, Fentanyl, Cholecystectomy