Endoplasmic reticulum stress and atherosclerosis

Abstract

Abstract: Endoplasmic reticulum stress has drawn much attention recently because of its potential roles in the pathomechanism of atherosclerosis.This review focused on the role of endoplasmic reticulum stress played in the initiation and development of atherosclerosis involving inflammation production, lipid metabolism dysfunction and cell apoptosis.Further more, some independent risk factors, such as hyperhomocysteinemia and hyperglycemia also induce the atherosclerosis via endoplasmic reticulum stress.

Key words: atherosclerosis, endoplasmic reticulum stress, inflammation, hyperhomocysteinemia, hyperglycaemia

CLC Number:

R541.4

FANG Xi, XUE Dan-ting, FANG Li, ZHANG Lu-yong. Endoplasmic reticulum stress and atherosclerosis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(8): 947-951.

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