Investigation of bioequivalence of capsules and tablets of complex chlorzoxazone in healthy volunteers

Abstract

Abstract: AIM :To investigate the bioequivalence between capsules and tablets of complex chlorzoxazone in healthy volunteers .METHODS:twenty volunteers were randomly divided into two groups ( test and reference) , ten in each, with crossover design .The concentration of com- plex chlorzoxazone was determined by HPLC and pharma- cokinetic parameters were calculated with DAS 2 .0 practi- cal pharmacokinetics program.RESULTS:The relative bioavalibility of chlorzoxazone and acetaminophen in com- plex chlorzoxazone capsules were ( 109 .1 ±30 .9) %and ( 114 .0 ±50 .5) %, respectively .CONCLUSION :The statistical analysis showed that the test and reference preparation were bioequivalent .

Key words: complex chlorzoxazone ;Bioequivalent , HPLC

CLC Number:

R969 .1

ZHU Jin-xiu, LI Jian-chun, HU Qi-sheng , DONG Hai-jun, GAO Shu, JIANG Zhi-wen. Investigation of bioequivalence of capsules and tablets of complex chlorzoxazone in healthy volunteers[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2006, 11(1): 78-81.

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Investigation of bioequivalence of capsules and tablets of complex chlorzoxazone in healthy volunteers

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