Study on IL-12, IL-10 expression of infants with none or low response to recombinant hepatitis B vaccine stimulated by bacillus Calmette-Guerin

Abstract

Abstract: AIM: To investigate the efficacy of Bacillus Calmette-Guerin (BCG) on IL-12, IL-10 expressions of infants with none or low response to recombinant hepatitis B vaccine. METHODS: The geometric mean titer (GMT) of anti-HBs was tested by radioimmunity assay after hepatitis B vaccine stimulation, selected 60 cases with non-or low-response(GMT <100 UL), who were divided into two groups, one group was injected by BCG, the concentrations of IL-10, IL-12 were detected by ELISA. RESULTS: BCG could significantly stimulate infants with none or low response to recombinant hepatitis B vaccine to product IL-12 and IL-10 associated cytokines, the enhancement was course-dependent.Compared with the control group, the GMT of anti-HBs was significantly higher than that in the Bacillus Calmette-Guerin injection group. CONCLUSION: BCG might be an effective adjuvant to induce cellular immune response via the enhancement of IL-12 and IL-10 of infants with none or low response to recombinant hepatitis B vaccine.

Key words: Bacillus Calmette-Guerin, recombinant hepatitis B vaccine, IL-12, IL-10

CLC Number:

R969

DI Jun-bo, CHEN Yi-ping, XU Zhi-wei. Study on IL-12, IL-10 expression of infants with none or low response to recombinant hepatitis B vaccine stimulated by bacillus Calmette-Guerin[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(11): 1296-1299.

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