Abstract: AIM: To investigate the effects of mangiferin purified from leaves of Mangifera indica L.on immunologic function in mice. METHODS: The olig-immunity model was made with hydrocortisone.The indexes of immune organs were calculated.The phagocytosis of mononuclear macrophage was determined with carbon particle clearance test.The spectrophotography was used to detect the levels of serum hemolysis IgG and IgM.The cell proliferation was measured by MTT assay. RESULTS: The mangiferin of 50 and 100 mg/kg significantly increased the phagocytic function, and recovered the indexes of the spleen and thymus in immunosuppressive mice caused by hydrocortisone.It also remarkably increased the levels of serum hemolysis IgG and IgM.The mangiferin could increase the proliferation of mouse spleen cells and macrophage. CONCLUSION: These results suggest that the mangiferin could enhance the non-specific immunity and humoral immunity in immunosuppressive mice.

Key words: mangiferin, non-specific immunity, humoral immunity