Abstract: AIM: To approach the protective effects of diammonium glycyrrhizinate phospholipid complex injection (DG-PC)on chronic and immunological liver injury. METHODS: The chronic and immunological hepatic liver injury was established in C57BL/6J mice, the levels of ALT, AST, TP,ALB and HA in serum were determined, the contents of SOD,GSH and collagen 1 (C.I)in liver homogenate were detected, and the liver tissue sections were observed by electron microscope. RESULTS: Compared with DG, DG-PC could significantly improve the AST level, increase the content of ALB, increase the A/G, decrease the content of HA(P<0.01), improve the activities of SOD and GSH(P<0.01).The therapeutic efficacy of DG-PC was better than that of DG.As to microstructure, DGPC could protect the hepatic cell and organelle, and relieve the fibrosis level. CONCLUSION: DG-PC has protective effects on chronic and immunological liver damage to C57 BL/6J mice, which maybe relate to the antioxidant effects.

Key words: diammonium glycyrrhizinate phospholipid complex, chronic and immunological liver injury, ultrastructure