Effects of MDR1 gene C3435T polymorphism on the steady-state plasma concentration and hypotensive activity of telmisartan

Abstract

Abstract: AIM: To study the effects of MDR1 C3435T polymorphism on steady-state plasma concentration and hypotensive activity of telmisartan. METHODS: 61 cases of essential hypertension patients were received oral dose of 40 mg telmisartan per day for 30 days.The genotyping of the MDR1 C3435T polymorphism in the patients was performed by using method of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).The plasma concentrations of telmisartan were determined by high performance liquid chromatograpy-Fluorescence detector (HPLC-FLD).The blood pressures of the patients were measured before and after treatment.The plasma concentrations and therapeutic effect of telmisartan were compared among the three different genotype groups. RESULTS: Among the 61 cases of elderly hypertension patients, the frequencies of 3435CC, 3435TT and 3435CT were 39.34%, 11.48% and 49.18%, respectively.There were no differences between healthy people and the hypertension patients in allele frequencies of MDR1 C3435T.The telmisartan steady-state concentration and curative effect also had no significant differences among the three genotype groups in the hypertensive patients. CONCLUSION: The MDR1 C3435T polymorphism does not affect the steady-state plasma concentrate and curative effect of telmisartan in hypertension patients.

Key words: multidrug resistance gene, P-glycoprotein, single nucleotide polymorphisms, telmisartan, steady-state plasma concentration

CLC Number:

R969

FAN Xiu-zhen, GUO Xin, WANG Hua-jie, CHENG Ze-neng. Effects of MDR1 gene C3435T polymorphism on the steady-state plasma concentration and hypotensive activity of telmisartan[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(6): 670-676.

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