Advancement on the therapy of somatostatin on liver fibrosis

Abstract

Abstract: Somatostatin, a cyclopeptide hormone, is generally distributed in vivo.Some studies have indicated that somatostatin can reduce proinflammatory cytokine in hepatic stellate cells and extracellular matrix, and inhibit their proliferation and contraction, promote their apoptosis.It can also regulate the function of Kupffer cells, influence the homing of hepatic stem cells.Somatostain has therapeutic effect on liver fibrosis, especially on the liver fibrosis caused by schistosoma mansoni.

Key words: somatostatin, hepatic stellate cell, hepatic fibrosis, liver cirrhosis, schistosoma mansoni

CLC Number:

R575

XU Xiao-bing, YANG Miao-fang, ZHU Ren-min. Advancement on the therapy of somatostatin on liver fibrosis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(6): 707-710.

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