Quantitation of drug concentration in hair and its application in drug monitoring

Abstract

Abstract: Hair can be easily collected, the collection method does not cause any harm to body.It can provide long and convinced information about drug uses.It possess irreplaceable advantages of blood, urine and other biological samples.The review summarizes the basic information and recent studies of hair analysis.It introducs the hair-shaft structure, the mechanisms of drug incorporation, extraction/purification methods and all kinds of analytical techniques.The advantages, drawbacks and promising prospects about hair in drug monitoring are also discussed.

Key words: hair, analysis, quantitation, monitoring

CLC Number:

R917

ZHANG Yu-shan, SONG Jian-guo. Quantitation of drug concentration in hair and its application in drug monitoring[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(6): 715-720.

References

[1] Goldblum RW, Goldbaum LR, Piper WN, et a1.Barbiturate concentrations in the skin and hair of guinea pigs[J]. Invest Dermatol, 1954, 22(2):121-128.
[2] Weiss D, Whitten B, Leddy D, et a1.Lead content of human hair[J].Science, 1972, 178(56):69-70.
[3] Baumgartner AM, Jones PF, BaumgartnerWA, et a1.Radioimmunoassay of hair for determining opiate-abuse histories[J].Nucl Med, 1979, 20(7):748-752.
[4] Nakahara Y, Takahashi K, Shimamine M, et al.Hair analysis for drug abuse[J].J Forensic Sci, 1991 36(1): 70-78.
[5] Henderson GL.Mechanisms of drug incorporation into hair [J].Forensic Science Internatlional, 1993, 63(1/2/3):19-29.
[6] Kikura R, Nakahara Y.Studies on mechanism of drug incorporation into hair [J].Kokuritsu lyakuhin Shokuhin Eisei Kenkyusho Hokoku, 1998,(116):30-45.
[7] Tsanaclis L, Wicks JF.Differentiation between drug use and environmental contamination when testing for drugs in hair[J].Forensic Sci Int, 2008, 176(1):19-22.
[8] Gratacós-Cubarsí M, CastellariM, Valero A, et al.Hair analysis for veterinary drug monitoring in livestock production[J].J Chromatogr B Analyt Technol Biomed Life Sci, 2006, 834(1/2):14-25.
[9] Morrison JF, Chesler SN, Yoo WJ, et al.Matrix and modifier effects in the supercritical fluid extraction of cocaine and benzoylecgonine from human hair[J].Anal Chem, 1998, 70(1):163-172.
[10] 凌文婷, 陈桂良, 徐伟东, 等.动物滥用药物的毛发分析[J].药物分析杂志, 2008, 28(9):1578-1582.
[11] Gallo P, Brambilla G, Neri B, et al.Purification of clenbuterol-like beta2-agonist drugs of new generation from bovine urine and hair by alpha1-acid glycoprotein affinity chromatography and determination by gas chromatographymass spectrometry[J].Anal Chim Acta, 2007, 587(1):67-74.
[12] Dunnett M, Lees P.Equine hair analysis:current status and future prospects[J].Equine Vet J, 2004, 36(2):102-103.
[13] Anderson RA, AriffinMM, Cormack PA, et a1.Comparison of molecularly imprinted solid-phase extraction (MISPE) with classical solid-phase extraction (SPE)for the detection of benzodiazepines in post-mortem hair samples [J].Forensic Sci Int, 2008, 174(1):40-46.
[14] Welch MJ, Sniegoski LT, Tai S.Two new standard reference materials for the determination of drugs of abuse in human hair[J].Anal Bioanal Chem, 2003, 376(8):1205-1211.
[15] Phinney KW, Sander LC.Liquid chromatographic method for the determination of enantiomeric composition of amphetamine and methamphetamine in hair samples[J].Anal Bioanal Chem, 2004, 378(1):144-149.
[16] Miyaguchi H, Kakuta M, Iwata YT, et al.Development of a micropulverized extraction method for rapid toxicological analysis of methamphetamine in hair[J].Chromatogr A, 2007, 1163(1/2):43-48.
[17] Cartmell LW, Aufderhide A, Weems C.Cocaine metabolites in pre-Columbian mummy hair[J].J Okla State Med Assoc, 1991, 84(1):11-12.
[18] Forman R, Schneiderman J, Klein J, et al.Accumulation of cocaine in maternal and fetal hair, the dose response curve[J].Life Science, 1992, 50(18):1333-1341.
[19] Uematsu T, Sato R.Human scalp hair as evidence of individual dosage history of haloperidol:longer-term followup study[J].Ther Drug Monit, 1990, 12(6):582-583.
[20] Matsuno H, Uematsu T, Nakashima M.The measurement of haloperidol and reduced haloperidol in hair as an index of dosage history[J].Br J Clin Pharmacol, 1990, 29(2): 187-194.
[21] Jurado C, Kintz P, MenéndezM.Influence of the cosmetic treatment of hair on drug testing[J].Int J Legal Med, 1997, 110(3):159-163.
[22] 孟品佳, 何洪源, 朱丹, 等.苯丙胺类毒品滥用者毛发中毒品及其代谢物[J].药物分析杂志, 2008, 28(5):709-714.
[23] Uematsu T, Yamada K, Matsuno H, et a1.The measurement of haloperidol and reduced haloperidol in neonatal hair as an index of placental transfer of maternal haloperidol[J].Ther Drug Monit, 1991, 13(2):183-187.
[24] Miyazawa N, Uematsu T, Mizuno A, et al.Ofloxacin in human hair determined by high performance liquid chromatography[J].Forensic Sci Int, 1991, 51(1):65-77.
[25] Uematsu T, Sato R, Fujimori O, et al.Human scalp hair as evidence of individual dosage history of haloperidol:a possible linkage of haloperidol excretion into hair with hair pigment[J].Arch Dermatal Res, 1990, 282(2):120-125.
[26] Uematsu T, Nakashima M, Fujii M, et al.Measurement of 5-fluorouracil in scalp hair:a possible index of patient compliance with oral adjuvant chemotherapy [J].Eur J Clin Pharmacol, 1996, 50(1/2):109-113.