Effect of oregano monomers against Trichomonas vaginalis in vitro

Abstract

Abstract: AIM: To study the effect of four monomers (thymol, cavacrol, rosmarinic acid and caffeic acid) extracted from oregano against Trichomonas vaginalis. MERHODS: The morphologic change, survival rate and MEC of the monomers on Trichomonas vaginalis were observed in different times and at different concentrations in vitro.RESULTS: The initial effect of Thymol and Cavacrol(5 mmol/L)against Trichomonas vaginalis was one time quicker than metronidazole.The MEC of thymol and cavacrol was 1.25, 2.5 mmol/L respectively at 24 h, which was respectively one and two times weaker than metronidazole.The effect of rosmarinic acid and caffeic acid on Trichomonas vaginalis was weak.CONCLUSIONS: Thymol and cavacrol have stronger effect against Trichomonas vaginalis.

Key words: thymol, cavacrol, rosmarinic acid, caffeic acid, metronidazole, Trichomonas vaginalis, minimal effective concentration

CLC Number:

R965.2

CHI Xiu-ling, YANG Qiu-lin, ZHU Bing-yang, YAN Yu-zhen, WEN Shu-guang, LI Lian, YAN Tao, ZHANG Hai-qiang, ZHONG Chao, TAN Hai-ping, YAN Feng-xiang. Effect of oregano monomers against Trichomonas vaginalis in vitro[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(2): 182-186.

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