Recent advance in association between genetic polymorphisms in CYP2C9 and pharmacokinetics and pharmacodynamics of sulphonylureas

Abstract

Abstract: Sulphonylureas are the initial and most commonly used therapy for type 2 diabetes mellitus.Sulphonylureas are metabolized by CYP2C9, and the CYP2C9 gene has several mutant alleles leading to genetic polymorphisms in humans.The variation of metabolism abilities of different CYP2C9 genotype is one of the reasons why the type 2 diabetes mellitus patients need different doses of sulphonylureas.To offer a guidance for individualizing administration of sulphonylureas, we specify the relationship between genetic polymorphisms in CYP2C9 and the pharmacokinetics and pharmacodynamics of sulphonylureas.

Key words: CYP2C9, genetic polymorphisms, sulphonylureas, pharmacokinetics, pharmacodynamics

CLC Number:

R966

HUANG Zuo-jun, LI Yue-ling, HUANG Min. Recent advance in association between genetic polymorphisms in CYP2C9 and pharmacokinetics and pharmacodynamics of sulphonylureas[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(2): 219-223.

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