Abstract: AIM: To observe the effect of polystyrene sulphur lanthanum on hyperphosphatemia in rat model with chronic renal failure induced by adenine. METHODS: Chronic renal failure of rats was induced by Yokozawz method through infusing adenine (0.3g·kg^-1·d^-1 ) for 25 days, and then model rats were given polystyrene sulphur lanthanum (1.500, 0.750, 0.375g·kg^-1·d^-1 ) and positive drug for 22 days, and the adenine was given continuously for another 10 days. During the experiment courses, the body weight, general status,appetite, urination and defecation were observed. And levels of BUN, Cr, P3 +, Ca2 +, K+, RBC, Hb, PLT,and HCT in blood were monitored after the drug was given for 10 and 21 days. Rats were killed for kidney pathology and a quotient calculation. RESULTS: The polystyrene sulphur lanthanum at a dose of 1.500 g·kg^-1 ·d^-1 could reduce the phosphor level significantly, and there was obviously different from that of control model group (P<0.05). CONCLUTION: The polystyrene sulphur lanthanum can significantly reduce the phosphor level of rat with chronic renal failure induced by adenine.

Key words: polystyrene sulphur lanthanum, chronic renal failure, adenine, blood phosphor