Abstract: AIM: To investigate the inhibitory effect of aspirin-niacinamide-zinc complex (Wuyisa, WUY) on human gastric carcinoma cell line SGC- 7901. METHODS: The inhibitory effect of WUY on SGC-7901 cells was evaluated by MTT analysis.The effect of WUY on SGC-7901 cell cycle was determined with flow cytometry. RESULTS: After treated with 2, 4, 8, 16 mmol/Lof WUY, the inhibition rates were 9.95 %, 19.28 %, 37.36 %, 63.47 % (P <0.05). The average IC50 of SGC-7901 cells was 11.06 mmol/L.The dose effect relationship and time effect relationship were described in the growth curve.The cell cycle distribution was changed in a concentrationdependent manner, after gastric cancer cell was treated for 24 hours with WUY by flow cytometry.Among phases of cell cycle, the G0 G1 phase ratio was decreased and the S and G0 M phase ratio were increased. CONCLUSION: WUY can obviously inhibit the growth of human gastric carcinoma cell line SGC- 7901 cells.It may be associated with the phases of cell cycle.

Key words: aspirin-niacinamide-zinc complex, SGC-7901 cell, inhibition, cell cycle