Abstract: AIM: To examine the effect of clinical pharmacists' intervention on compliance of aspirin. METHODS: 262 cardiovascular patients with hypertension, diabetes, coronary heart disease, stroke or hyperlipemia were randomly chosen.Clinical pharmacists gave the patients four lessons about aspirin, such as the effect of aspirin to prevent and cure cardiovascular diseases, the canonical dosage, usage and course, the skill how to reduce adverse reactions of aspirin et. Blooding time, clotting time, routine blood test, liver function and kidney function were examined before and after the intervention. RESULTS: After four lessons about aspirin given, all the patients gained more confidence in aspirin to prevent cardiovascular disease.IPSs of the four measurement indicators of the compliance (the number, the dosage, the time, and long-term medication by doctors) were excellent than before the lessons.The occurrence rates of gastrointestinal reactions, bleeding tendency, thrombophilia, abnormal liver function were reduced significantly, the rates of abnormal kidney function, nervous system reactions and coagulopathy were reduced too.The compliance after intervention (68.3 %) was higher than the compliance before intervention (23.3 %) dramatically and the difference was statistically significant(P <0.05). CONCLUSION: Clinical pharmacists can improve medication compliance of aspirin by active intervention such as give lessons.

Key words: aspirin, cardiovascular disease, intervention, compliance