Progress on anti-cancer mechanisms of natural coumarins

Abstract

Abstract: Many literatures on anti-cancer activities of natural occurring coumarins are available.The anti-cancer mechanisms of coumarins are related to the physiological modulations in the living body.This paper is aimed to review the anti-cancer mechanisms of coumarins from different aspects such as influences on cell cycles, induction of cell apoptosis, SAPK JNK p38MAP signaling pathways and the system of glutathione S-transferases (GST) NADPH quinine oxidoreductase (NQO).

Key words: coumarins, anti-cancer mechanism, cell cycles, apoptosis, signaling pathways

CLC Number:

R966

WU Long-huo, LI Pei, DIAO Yong, XU Rui-an. Progress on anti-cancer mechanisms of natural coumarins[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(10): 1174-1177.

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