Protective effects of crocetin on cerebral ischemia-reperfusion injury in mice

Abstract

Abstract: AIM: To research the protective effects of crocetin on cerebral ischemia-reperfusion (CIR)injury in mice.METHODS: The effects of crocetin on brain edema , brain capillary permeability , the activities of lactate dehydrogenase (LDH), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px) in brains and the contents of malondialdehyde (MDA)and nitric oxide(NO)in CIR model mice were observed.RESULTS: Compared with the CIR group , crocetin (50 ,100 mg/kg for 5 d )decreased the content of water , Evans blue , MDA and NO in mice brain tissue , and increased LDH 、SOD and GSH-Px activity in brains of CIR mice , with statistical significance.CONCLUSION: Crocetin has protective effects on cerebral ischemia-reperfusion injury in mice , the mechanism may be related to its anti-oxidative activity and inhibition of NO overproduction.

Key words: crocetin, cerebral ischemia reperfusion injury, lipid peroxidation, nitrogen monoxidum

CLC Number:

R965.2

GAO Cong , PENG Fei-cheng ,QIAN Zhi-yu. Protective effects of crocetin on cerebral ischemia-reperfusion injury in mice[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(4): 421-425.

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