Effects and mechanisms of hepatic stellate cells (HSC)activation and proliferation-related signal transduction pathway in liver fibrosis

Abstract

Abstract: The activation and proliferation of hepatic stellate cell(HSC)have been considered to play an important role in hepatic fibrosis.The manipulation of the activation and proliferation of hepatic stellate cells and the process of liver fibrosis inversion are the key in anti-liver-fibrosis researches.This paper briefly reviews the hepatic stellate cells (HSC)activation and proliferation-related signal transduction pathway and explores the role in the pathogenesis of liver fibrosis.It is a new way to study the pathogenesis and therapy of liver fibrosis through intervention of HSC activation and proliferation-related signal transduction pathway.

Key words: hepatic stellate cell, liver fibrosis, signal pathways

CLC Number:

R575.5

BAO Jia-chun, YUAN Feng-lai, LU Wei-guo, LI Xia, WU Fan-rong, CHEN Fei-hu. Effects and mechanisms of hepatic stellate cells (HSC)activation and proliferation-related signal transduction pathway in liver fibrosis[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2009, 14(4): 455-459.

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