Abstract: AIM: To observe the therapeutic effect of total flavones bidens pilosa L (TFB) on experimental schistosoma japonicum hepatic fibrosis in mice.METHODS: 50 mice infected with schistosma japonicum cercariae percutanoeusly were divided into 5 groups :model group, TFB 57.5, 115, 230 mg/kg group and Colchicines 0.15 mg/kg group and other 10 normal mice were used as control group.After treatment with TFB for 8 weeks, the spleen and liver were removed and weighed. The contents of ALT, AST, albumin(ALB) and total proteins (TP) in serum were assayed using the corresponding kits.Moreover, histopathological changes in hepatic tissues were examined and the degree of liver fibrosis was scored.RESULTS: The mice that infected with schistosoma japonicum, had a featuring increment in spleen and liver weights, serum ALT, AST and EPG contents, decrease in serum ALB and TP contents.TFB (230 mg/kg) treatment significantly reduced serum ALT, AST and EPG contents (P<0.01).In addition the hepatic histopathology was also improved in TFB treatment group (115, 230 mg/kg) (P<0.01).CONCLUSION: TFB has significant therapeutic effect on schistosoma japonicum-induced liver fibrosis in mice.

Key words: total flavones bidens pilosa L, schistosomiasis, hepatic fibrosis