Abstract: AIM: To observe the prevention and cure effects of Shu Dan Tong granules(SDT) on experimental cholelithiasis in guinea pigs. METHODS: 62 DHA guinea pigs were randomly divided into normal group, model control group, positive control group, as well as SDT 5, 10, 20 g (crude drug, the same below)/ kg dose group, feed with high cholesterol and low protein lithogenic diet in addition to the normal group, and all guinea pigs in different group were given corresponding drugs simultaneously by gavage administration for 70 days, and the general condition, stone formation, bile secretion and composition, blood biochemistry were observerd or detected. RESULTS: SDT can significantly improve the general condition of cholelithiasis in guinea pigs, lower lithogenesis rate and improve total bile acid (TBA) content in doses of 5, 10, 20 g/kg, and can significantly improve the bile secretion and plasma cholecystokinin (CCK) levels, lower serum total cholesterol (TC) levels in doses of 10, 20 g/kg. CONCLUSION: SDT has the prevention and cure effects on cholelithiasis modle of guinea pigs.

Key words: Shu Dan Tong granules, cholelithiasis, prevention and cure effects, experimental study