Abstract: AIM: To study the pharmacokinetics of memantine in healthy Chinese volunteers after single and multiple doses of memantine hydrochloride capsule. METHODS: The concentration of memantine in human plasma was determined by HPLC-MS MS method and its pharmacokinetic parameters were calculated by DAS 2.0.RESULTS: The main pharmacokinetic parameters of memantine after single oral dose of 5, 10, 15 mg memantine hydrochloride capsule were as follows: t_max were (5.6±1.2), (5.2±2.0) and (4.9±1.1) h.C_max were(4.4±0.9), (8.9±1.6) and (16.5±2.8) ng/mL, t_1/2 were (47±10), (47± 9) and (51± 9) h, and after multiple oral dose of 10 mg memantine hydrochloride capsule were as follows: t_max was(6.0±1.4) h, C_max was(32±6) ng/mL, t_1/2 (46±8) h. CONCLUSION: A dose relationship of C_max and AUC existed after single oral doses of 5, 10 and 15 mg memantine hydrochloride capsule.There is accumulation after a multiple dose of 10 mg once daily administration.

Key words: memantine, liquid chromatographytandem mass spectrometry, pharmacokinetics