Advances in study of estrogen and its receptors signal transduction pathway

Abstract

Abstract: Estrogen gradually becomes the research hot spot because it has extensive biological effect, which exerts its function by binding to estrogen receptors (ERs).ERs have the widespread organization distribution, including the reproductive system, the skeleton and the cardiovascular system, and these provided the guarantee for the estrogen to display biology effect.This article reviews the advance of estrogen and its receptors signal transduction pathway in abroad and domestic.

Key words: estrogen, estrogen receptors, signal transduction, advances in study

CLC Number:

R966

FAN Guan-wei, HE Jun, WANG Hong, GAO Xiu-mei. Advances in study of estrogen and its receptors signal transduction pathway[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2007, 12(3): 266-269.

References

1 Greene GL, Gilna P, Waterfield M, et al.Sequence and expression of human estrogen receptor complementary DNA[J]. Science, 1986;231:1150-1154.
2 Kuiper GG, Enmark E, Pelto-Huikko M, et al.Cloning of a novel estrogen receptors expressed in rat prostate and ovary[J]. Proc Nat Acad Sci USA, 1996;93:5925-5930.
3 Mosselman S, Polman J, Dijkema R.ERβ:identification and characterization of a novel estrogen receptor[J].FEBS Lett, 1996;392:49-53.
4 葛秦生.临床生殖内分泌学[M].北京:科学技术文献出版社, 2001:210-211.
5 谈智, 王庭槐.雌激素作用分子机制研究进展[J].中国病理生理杂志, 2003;19:1422-1426.
6 荣顺兴, 金泰廙.ER 的研究进展[J].职业卫生与应急救援, 2005;21:11-14.
7 Shang YF, Hu X, James DR, et al.Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription [J]. Cell, 2000;103:843-852.
8 Smith CL.Cross-talk between peptide growth factor and estrogen receptor signaling pathways[J].Biol Repord, 1998;58:627-632.
9 Ueda S, Tsuda H, Sato K, et al.Alternative tyrosine phosphorylation of signaling kinases according to hormone receptor status in breast cancer overexpressing the insulin-like growth factor receptor type 1[J].Cancer Sci, 2006;97:597-604.
10 Ignar-Trowbridge DM, Nelson KG, Bidwell MC, et al.Coupling of dual signaling pathways:epidermal growth factor action involves the estrogen receptor[J].Proc Natl Acad Sci, USA, 1992;89:4658-4662.
11 Lannigan DA.Estrogen receptor phosphorylation[J].Steroids, 2003;68:1-9.
12 Kato S.Estrogen receptor-mediated cross-talk with growth factor signaling pathways[J].Breast Cancer, 2001;8:3-9.
13 Tremblay A, Giguere V.Contribution of steroid receptor coactivator-1 and CREB binding protein in ligand-independent activity of estrogen receptor beta[J].J Steroid Biochem Mol Biol, 2001;77:19-27.
14 Paech K, Webb P, Kuiper GG, et al.Differential ligand activation of estrogen receptors ERαand ERβ at AP1 sites[J].Science, 1997;277:1508-1510.
15 Koji H, Jeffrey RB.Vascular cell signaling by membrane estrogen receptors[J].Steroids, 2005;70:382-387.
16 Kousteni S, Bellido T, Plotkin LI, et al.Nongenotropic, sexnonspecific signaling through the estrogen or androgen receptors: dissociation from transcriptional activity[J].Cell, 2001; 104:719-730.
17 Razandi M, Pedram A, Levin ER.Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer[J].Mol Endocrinol, 2000;14:1434-1447.
18 Benten WP, Stephan C, Lieberherr M, et al.Estradiol signaling via sequestrable surface receptors [J].Endocrinology, 2001;142:1669-1677.
19 Herynk MH.Fuqua SA1 Estrogen receptor mutations in human disease[J].Endocri Rev, 2004;25:869-898.
20 Marino M, Acconcia F, Ascenzi P.Estrogen receptor signalling: bases for drug actions[J].Curr Drug Targets Immune Endocr Metabol Disord, 2005;5:305-314.
21 Gustafsson J.Estrogen receptor β₂ a new dimension in estrogen mechanism of action[J].J Endocrinol, 1999;163:379-383.
22 Pare G, Krust A, Karas RH, et al.Estrogen receptor-alpha mediates the protective effects of estrogen against vascular injury [J].Circ Res, 2002;90:1087-1092.
23 Zhu Y, Bian Z, Lu P, et al.Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta[J]. Science, 2002;295:505-508.

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