Welcome to Chinese Journal of Clinical Pharmacology and Therapeutics,Today is Chinese

Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2006, Vol. 11 ›› Issue (11): 1225-1229.

Previous Articles     Next Articles

Progress of “Cocktail” probe substrates approaches

LIU Ying, JIAO Jian-jie, LOU Jian-shi   

  1. Department of Pharmacology , Tianjin Medical University , Tianjin 300700 , China
  • Received:2006-06-09 Revised:2006-07-10 Online:2006-11-26 Published:2020-11-06

Abstract: The method of simultaneous administration of several probe substrates is called “Cocktail” approaches.The objective of the article is to review the application of this technique in characterizing the activity of multiple drug-metabolizing enzymes and in clinical researches.This paper also shows Five-drug and Six-drug Cocktail set for evaluating in vivo activity of drug-metabolizing enzymes.

Key words: Cocktail, cytochrome P450, application

CLC Number: