Myocardial ischemia/reperfusion injury and inflammatory reaction

Abstract

Abstract: In both clinical and animal experiments, it has been confirmed that the inflammation in heart is involved in the development of heart injury after the ischemia/reperfusion. However, the pro-inflammatory mechanism is extremely complicated. Recently, a growing number of reports indicates that many factors play their roles in the inflammation, such as cytokinemia, inflammatory cells, metabolic product of arachidonic acid and COX et al. They are released/presented in the region of myocardial ischemia/reperfusion and include both ischemic and secondary heart injury.

Key words: ischemic/reperfusion, cytokinemia, inflammatory cell, metabolic product of arachidonic acid, cycloxygenase

CLC Number:

R965

DONG Liu-yi, CHEN Zhi-wu. Myocardial ischemia/reperfusion injury and inflammatory reaction[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2008, 13(5): 582-588.

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