Effects of uroacitides on proliferation ability of breast cancer cells

Abstract

Abstract: AIM: To investigate the growth inhibition effects of CDA-II on breast cancer cells. METHODS: The effects of CDA-II on growth curve and morphology of breast carcinoma cell lines MCF-7 and MDA-MB-231 were observed in vitro cultures. RESULTS: CDA-II reduced the growth speed and proliferation ability. CONCLUSION: CDA-II has remarkable effects on anti-cellproliferation and shows good prospects of application in the treatment of patients with breast carcinoma.

Key words: breast carcinoma, uroacitides (CDAII), retinoic acid, cell culture

CLC Number:

R979.1

WANG Yan-hong, ZHENG Wei. Effects of uroacitides on proliferation ability of breast cancer cells[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(6): 677-681.

References

1 Wang JJ, Chang YF, Chern YT, CW Chi. Study of in vitro and in vivo effects of 1, 6-Bis[4-(4-amino-3-hydroxyphenoxy) phenyl] diamantine (DPD), a novel cytostatic and differentiation inducing agent, on human colon cancer cells[J]. Br J Cancer, 2003;89: 1995-2003
2 Li XN, Du ZW, Huang Q, Wu JQ. Growth-inhibitory and differentiation-inducing activity of dimethylformamide in cultured human malignant glioma cells[J]. Neurosurgery, 1997; 40: 1250-9
3 Greenwood EM, Ito A, Westenburg H, Cui B, Menta RG, Kinghorn AD, et al.Discovery of novel inducers of cellular differentiation using HL-60 promyelocytic cells[J]. Anticancer Res, 2001;21: 1763-70
4 Lebeau A, Unholzer A, Amann G, Kronawitter M, Bauerfeind I, Sendelhofert A, et al.EGFR, HER-2 /neu, cyclin D1, p21 and p53 in correlation to cell proliferation and steroid hormone receptor status in ductal carcinoma in situ of the breast[J]. Breast Cancer Res Treat, 2003;79:187-98
5 Chow LWC, Loo WTY.The differential effects of cyclophosphamide, epirubicin and 5-fluorouracil on apoptotic marker (CPP-32), pro-apoptotic protein (p21 waf-1) and anti-apoptotic protein (bcl-2) in breast cancer cells[J]. Breast Cancer Res Treat, 2003;80: 239-44
6 孙立军, 黄强, 王爱东, 兰青, 杜子威, 胡庚熙.建立胶质瘤细胞诱导分化相关基因谱[J]. 中华肿瘤杂志, 2002;24:222-5
7 谭立军, 汤雪明, 沈忠英, 许锦阶.二甲基亚砜诱导人食管癌细胞分化的实验研究[J]. 实验生物学报, 1998;31:353-68
8 廖明征, 主编.聪明的抗癌药CDA-II[M]. 第1 版.台北: 世茂出版社, 1999;139-213
9 冯奉仪, 李青, 王振玖.尿多酸肽改善晚期癌症患者生活质量的临床研究[J]. 中国肿瘤, 2002; 11:108-10
10 孙婧王景, 周信达, 刘银坤, 吴志全, 施建英, 高冬梅.细胞分化诱导剂防治裸鼠肝癌转移复发的疗效[J]. 中华肝胆外科杂志, 1999; 5:14-6
11 刘建伟, 唐毅, 沈雁, 钟学云.三氧化二砷和细胞分化剂诱导肝癌细胞凋亡的阈值[J]. 中华实验外科杂志, 2003; 20:116-7
12 Swami S, Raghavachari N, Muller UR, Bao YP, Feldman D. Vitamin D growth inhibition of breast cancer cells:gene expression patterns assessed by cDNA microarray[J]. Breast Cancer Res Treat, 2003;80: 49-62
13 Hayden LJ, Satre MA.Alteration in cellular retinal metabolism contribute to differential retinoid responsiveness in normal human mammary epithelial cells versus breast cancer cells[J]. Breast Cancer Res Treat, 2002;72: 95-105
14 Shao ZM, DawsonMI, Li XS, Rishi AK, Sheikh MS, Han QX, et al.p53 independent G₀ /G₁ arrest and apoptosis induced by a novel retinoid in human breast cancer cells[J]. Oncogene,1995;11:493-504
15 Seewaldt VL, Kim JH, Parker MB, Dietze EC, Srinivasan KV, Caldwell LE.Dysregulated expression of cyclin D1 in normal human mammary epithelial cells inhibits all-trans-retinoic acidmediated G₀ /G₁-phase arrest and differentiation[J]. Experimental Cell Res, 1999;249:70-85

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