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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (2): 121-124.

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Molecular mechanism of protective effects of estrogen on cerebral ischemia

HUANG Qian, LU Ying-Qing   

  1. Department of Pharmacology, Medical College, Fudan University, Shanghai 200032, China
  • Received:2003-11-04 Revised:2003-11-19 Online:2004-02-26 Published:2020-11-16

Abstract: Estrogen has the protective effect on cerebral ischemia in various ways.It not only can improve the regional cerebral blood flow during ischemia and rescue the remaining neurons alive, but also can reduce the injury of ischemia-reperfusion.In this article, we enumerate at the molecular level that estrogen has the properties of inhibiting the expression of VCAM and cytokines like TNF-αin the ischemia region, educing the overload of calcium and cytotoxicity of EAA by modulating the calcium channels, and regulating related genes expression and anti-apoptosis.It is crucial for estrogen replacement therapy as a neutoprotectant clinically.

Key words: estrogen, cerebral ischemia, neuroprotective, cerebral blood flow (CBF), apoptosis, estrogen receptor

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