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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2004, Vol. 9 ›› Issue (2): 204-207.

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Evaluation of clinical effect of laozhiling oral liquid on vascular dementia

GAO Chang, WANG Jing-Zhou   

  1. Department of Neurology, Daping Hospital of the Third Military Medical University, Chongqing 400042, China
  • Received:2003-08-21 Revised:2003-08-21 Online:2004-02-26 Published:2020-11-16

Abstract: AIM: To study the effect of laozhiling oral liquid (LZL) in treating vascular dementia.METHODS: Patients were randomly divided into two groups:39 patients in the LZL treated group and 32 patients in the control group treated by Jinnaduo injection with therapeutic course of 3 months.Changes of minimental state examination (MMSE), Hasegawa' s Dementia Scale (HDS),activity of daily living (ADL) scores and levels of Angiotensin Ⅱ(AngII), Arginine vesopresin (AVP) and P300PL in cerebrospinal fluid were observed.RESULTS: The total effective rates in the LZL and Jinnaduo group were 61.54 % and 59.38 %, respectively, which had no significant difference between the two groups(P >0.05). MMSE, HDS scores of patients and the concentration of AVP could be obviously elevated (P<0.01), but the scores of ADL and levels of AngII markedly decreased (P<0.01).CONCLUSION: LZL has definite effect in treating VD and its therapeutic mechanism may be related to the actions of improving the function of neuropeptides.

Key words: laozhiling oral liquid (LZL), vascular dementia, cognition function, angiotensin II, arginine vasopresin

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