Abstract: AIM: To study the effects of gender difference on the pharmacokinetics of oral cyclosporin A in renal transplanted recipients.METHODS: The study included 21 male patients and 20 female patients treated with CsA at 6 mg·kg^-1 ·d^-1 for two weeks.Each patient was involved in pharmacokinetics of CsA by fluorescence polarization immunoassay.RESULTS: The pharmacokinetic parameters of CsA in male and female renal transplanted recipients were:tmax (h):2.9±1.0 and 2.2±0.9 ;C_max (mg·L^-1):1.0±0.4 and 0.9±0.5 ;C_min(mg·L^-1):0.20±0.09 and 0.17±0.11 ;T1 2(a) (h):0.8±0.6 and 0.7±0.5 ;T1 2(e) (h):3.0±1.2 and 2.8±0.8 ;AUC0-12 (mg·L^-1) ·h-1:5.5±1.4 and 4.5±1.7 ;CL F(L·h^-1):40±25 and 47±35, and V F(C)(L):159±108 and 172±92, respectively.CONCLUSION: There is gender difference of pharmacokinetics of oral cyclosporin A in renal transplanted recipients.

Key words: cyclosporin A, renal transplanted recipients, pharmacokinetics, gender difference