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Chinese Journal of Clinical Pharmacology and Therapeutics ›› 2005, Vol. 10 ›› Issue (3): 298-301.

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Determination of scutellarin in human plasma by LC-MS method and its clinical pharmacokinetics in Chinese healthy volunteers

JU Wen-zheng1,2,3, ZHANG Jun1,2, Tan Hen-shan4, JIANG Meng1, CHEN Ming1,2, XIONG Ning-ning1   

  1. 1Department of Clinical Pharmacology, Affiliated Hospital, Nanjing University of Traditional Chinese Medicine, 2Jiangsu-Anhui Provincial United Laboratory for the Clinical Pharmacokinetics of Traditional Chinese Medicine and Western Medicine, Nanjing 210029, Jiangsu, China;
    3School of Life Science, Nanjing University, Nanjing 210093, Jiangsu, China;
    4General Hospital of Armed Forces of Nanjing, Nanjing 210002, Jiangsu, China
  • Received:2005-01-27 Revised:2005-03-12 Online:2005-03-26 Published:2020-11-18

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Abstract: AIM: To determination of scutellarin in human plasma by LC-MS method and investigate the pharmacokinetics of breviscapine tablets in Chinese healthy volunteers.METHODS: 20 male healthy volunteers were received a single oral dose of 120 mg breviscapine tablets.The plasma concentration of scutellarin aglycone was determined by HPLC-MS method.RESULTS: The linear range was 3.24-0.0126 mg°L-1.Within-day RSD and between-day RSD were less than 12%.The main pharmacokinetic parameters were as follows:Tmax was 7.0±2.3 h, Cmax was 0.9±0.5mg°L-1, AUC0-24h was 5.6±1.6 mg°h°L-1, AUC0-∞ was 5.8±1.6 mg°h°L-1, MRT0-24h was 8.0±1.1 h, and MRT0-∞ was 8.6±1.4 h.CONCLUSION: This method is sensitive, fast, and accurate, and it can be used for pharmacokinetic studies of scutellarin in humans.

Key words: breviscapine tablets, scutellarin, plasmadrug concentration, LC-MS, pharmacokinetics

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