Abstract: AIM: To analyze the bacterial resistance of clinical isolates in a hospital.METHODS: Suscepti-bility of 285 strains of G-bacillus and 133 strains of G+bacillus was observed in 18 kinds of antibiotics.RE-SULTS: Resistance increased in most G-bacilli to the third generation cephalosporin.The resistance rate was 28.4%in the 74 strains of staphylococcus aureus,and 3.4 %in enterococci to vancomycin.No vancomycin re-sistant strain was found.Extend spectrumβ-lactamases of E.coli and klebsiella (ESBLs)accounted for 34.0%and 29.7%,respectively.CONCLUSION: The drug resis-tance issevere in antibiotics,indicating that susceptibility determination is important in selection of antibiotics.

Key words: pharmacodynamics, clinical isolates, drug resistance, antibiotics, surveillance, efficacy evalu-ation