Abstract: AIM: To investigate the therapeutic ef-fects of the marine capsules combined with composite Salvia miltiorrhiza dropping pill in treatment with patients with hepatic fibrosis related to chronic hepatitis B. METHODS: 54 patients were enrolled and randomly di-vided into control group and treatment group.The liver function, the marker of hepatic fibrosis and hepatitis B virus were determined before and after therapy. RESULTS: The markers in this study were significantly im-proved than those before treatment and those in control group (P<0.05 or P<0.01). CONCLUSION: The marine capsules combined with composite Salvia miltior-rhiza dropping pill can effectively control the activity of liver inflammation in the patients with chronic hepatitis B and markedly heighten the effects in treatment of patients with hepatic fibrosis and inhibit the replication of HBV without severe side effect.

Key words: chronic hepatitis B, marine capsules, composite Salvia miltiorrhiza dropping pill, hepatic fibro-sis