Abstract: AIM: To study the pharmacokinetics and pharmacodynamics of salviol B in healthy volunteers and explore the relationship between the blood concentration of salviol B and the platelet aggregation and adhesiveness. METHODS: Nine male volunteers were administered 200, 300 and 400 mg salviol B (ivgtt) by cross-over design. The blood samples of different time points in these subjects were sampled and the drug concentrations of salviol B were analyzed by HPLC. The rates of platelet aggregation and adhesiveness were determined by efficacy indices. RESULTS: Salviol B was a two-compartment model with fast elimination (t_1/2, 1 h) and a large apparent volume of distribution. The C_maxwas 14 mg·L^-1. The rates of platelet aggregation and adhesiveness decreased after administration, and it was related to the change of drug concentration. The effect hysteresis rings were found from the curves of efficacy-concentration. CONCLUS-SION: Salviol B can decrease the rates of platelet ag-gregation and adhesiveness with efficacy hysteresis. It is an agent with fast elimination.

Key words: pharmacokinetics, salviol B, platelet aggregation, platelet adhesiveness, HPLC, PD-PK analysis