Abstract: AIM: To investigate the effects of saponin of Litchi seed (SL) and roglitazone on decreasing blood glucose, Lipid and amelioration hepatic, nephritic function in hyperlipemia-fatty liver rats fed by high-sugarfat.METHODS: The animal model with hyperlipemiafatty liver was prepared in rats by feeding on high caloric diet (abounded of sugar and fat) for 10 weeks.After 6 weeks treatment, the effects of SL, roglitazone and gliclazide (intragastrointestinally administered, qd for 4 weeks) on fasting blood glucose (FBG), 2-hour blood glucose (2hBG) after oral glucose tolerance test (OGTT), serum contents of fasting glucose(FSG), total cholesterol(TC), triacylglycerol (TG), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), blood urea nitrogen (BUN), creatine (Cr) and serum activities of alanine aminotransferase (ALT), and aspartate aminotransferase (AST) and hepatic histopathology were observed by microscope.RESULTS: After administration of SL and roglitazone, the serum concentrations of fasting blood glucose (FSG) and 2-hour blood glucose (2hBG) after oral glucose tolerance test (OGTT) significantly decreased (P <0.05);the impaired glucose tolerance (IGT) improved;the level of TG, TC, and LDL-C decreased (P <0.05);the content of HDL-C augmented (P <0.05);the concentrations of BUN and Cr, activities of ALT and AST decreased (P <0.05);and the fatty degeneration of hepatocytes improved (P <0.01). CONCLUSION: SL and roglitazone can control hyperinsulinemia, enhance insulin sensitivity, reduce level of blood glucose, regulate components and contents of blood lipid, and improve both of function in liver and kidney.

Key words: saponin of Litchi, roglitazone, insulin resistance, hyperlipemia, fatty liver