Effects and mechanisms of rosiglitazone on insulin resistance in rats with hyperlipemia

Abstract

Abstract: AIM: To study the effects and mechanisms of rosiglitazone and gliclazide on insulin resistance in rats induced by high-fat diet and hyperlipemia. METHODS: After seven weeks feeding with high-fat diet, the rats with insulin resistance were divided into 3 groups:the control group, the rosiglitazone group and the gliclazide group.Insulin and glucose tolerance were tested.Concentrations of tumor necrosis factor-α(TNF-α) and fasting insulin (Fins) in serum and triacylglycerol (TG), malondialdehyde (MDA), superoxide dismutase (SOD) and glutathione (GSH) were determined in hepatic.RESULTS: The state of impaired glucose tolerance (IGT) was improved, the concentrations of fasting glucose (FSG), TNF-α, TG and MDA were decreased (P < 0.05), and the deposit of GSH were increased (P < 0.01) by rosiglitazone and gliclazide.The high insulin level and the concentrations of blood (BUN), creatine (Cr) and Fins were decreased and the sensitivity of insulin (ISI) (P <0.05) was increased by rosiglitazone. CONCLUSION: Rosiglitazone can improve the insulin resistance in rats induced by high-fat diet and hyperlipemia.

Key words: roglitazone, gliclazide, insulin resistance, high-fat diet, hyperlipemia, rats

CLC Number:

R977.15

ZHENG Lin-ying, PAN Jing-qiang, LIN Jie-ru, XIAO Liu-ying, LI Bo-ping, HAN Chao. Effects and mechanisms of rosiglitazone on insulin resistance in rats with hyperlipemia[J]. Chinese Journal of Clinical Pharmacology and Therapeutics, 2005, 10(1): 96-99.

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